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Hepatitis | Hepatitis Virus Research | Hepatitis Virus Treatment by ILBS in Delhi, NCR, India

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Hepatitis | Hepatitis Virus Research | Hepatitis Virus Treatment by ILBS in Delhi, NCR, India Online Patient Services OPD Days Online Lab Report Make An Appointment Online Payment Find A Doctor Pre-Registration Forms Today's Bed Status Download E Yakrit Mobile App Preventive Health Checkup Our Services EWS Category Patient Stories Cashless TPAs (Corporate Only) Academics NIRF NAAC Accredition Message From AcademicsLaminaCourses Admissions Enrolled Students Faculty Library Alumni Faculty Lecture International/Visiting Faculty Lectures Fellowship Conferences Committiees College Of Nursing Academics Outreach Program Photo Gallery Research Regenerative Medicine And Bio-designing HepatomicsVigilantOn Chronic Liver Failure Liver Degenerative Changes Liver Multi Omics Hepatitis Virus Research Workshop - Biostatistics Liver Helpline No. 1800115354 Ambulance No.011 4630 0000 Reception / Enquiry No.011-26706700-02, 46300000 Click Here The only centre under GNCTD performing Liver and Kidney transplants. 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Hepatitis B Virus Persistence leads to HCC In India, the prevalence of chronic HBV infection in pregnant sexuality is 0.82% (4) and during pregnancy, hepatitis B virus infection presents the risk of mother-to-child (vertical) transmission. 15-40% of HBV infected patients would develop cirrhosis, liver failure, or HCC. Our work has revealed (Trehanpati et al 2009, 2011, 2012) that during vigilant HBV (AVH-B) and chronic HBV (CHB) infection in adults; CD4+ T cells exhibit unshared gene signatures between the two variegated modes of infection. In the study on sultana CHB under treatment with antiviral therapy, we found that the frequency of FoxP3 expressing Tregs in thoroughbred decreases withal with a subtract of viral load in eAg+ve patients. It was moreover observed that FoxP3 expressing CD4+CD25+regulatory T cells have a role in setting up of chronicity in HBV patients with cirrhosis and HCC (Fig. 1). Fig. 1: Immune regulation with antiviral in HBV infection. A-B. In sultana CHB patients under treatment with antiviral therapy, the frequency of Tregs in thoroughbred was found to subtract withal with the subtract of viral load. C. Normal liver showing  low expression of FoxP3 protein  in comparison to  chronic hepatitis B, cirrhosis and HCC tumor tissue. Regulation of regulatory T cells during HCC Our work highlights the key role of Notch and TGF-β signaling in generation of antigen specific regulatory T cells. During cirrhosis and remoter in HCC enhanced the expression of these key molecules is associated with increased emergence of FoxP3 regulatory T cells, which probably contributes to the chronicity and fibrogenesis (Fig. 2). Cellular mechanisms involved in persistent hepatitis B virus replication during pregnancy In a preliminary study on newborns, we have found that FoxP3 regulatory T cells are upper in HBsAg+ve neonates born to HBsAg+ve mothers. Furthermore, HBsAg+ newborns were found to exhibit reduced B lamina population. Our data suggests that perinatal HBV infection might globally stupefy the immune system in newborns and continuous exposure of the HBV in utero leads to defect in phenotype and functionality of T cells. Our aim is to dissect why few HBsAg+ve neonates born to HBsAg+ mothers resolve HBV infection while in others it persists. We hope our ongoing studies may help in future to resolve this issue for largest management of the neonates with persistent infection. Genome wide expression profiling for identifying gene expression signatures and microRNA profiles in HBV associated liver disease progression The outcome of persistent infection by HBV and  minutiae of liver disease are unswayable by viral /host factors.. In this regard microRNA (miRNA) tenancy has emerged as a hair-trigger regulatory principle in the mammalian immune system.  Therefore, our aim is to identify regulation of various miRNAs and their target genes during hepatitis B viral infection, which will provide new insights to study the host-pathogen interactions and the mechanism overdue viral persistence. We undertook a study to determine the miRNA profile of CD4+ and CD8+ T cells from liver biopsy samples from healthy control, Chronic HBV-infected patients HBV-cirrhotic patients and HBV related HCC patients (Fig. 1). We are currently in the process of analyzing the microRNA expression signatures using nomenclature algorithms such as DT (Decision Tree), NN (Neural Network) and SVM (Support Vector Machine), to find predictor genes and biomarkers which potentially can be used for diagnostic applications. 2.5 Investigations on antiviral effects of monoherbal preparations and their  phytochemicals versus Hepatitis B virus   The treatment of chronic HBV infection includes intereferons, nucleoside and nucleotide analogs. The efficacy of these teachers is limited, and their use is associated with side effects and emergence of drug resistance. Medicinal plant formulations and other phytochemical compositions have been used for generations as anti-viral agents, although scientific investigations have been lacking in their efficacy and mechanism of action. Several of these phytochemicals have complementary and overlapping mechanism of action, including anti-viral effects by either inhibiting the insemination of viral DNA or RNA or inhibiting the worriedness of viral reproduction. In view of this a primary goal of our study is to identify herbal drug and its zippy components in inhibiting the HBV replication in hepatic cells, either directly or indirectly by well-expressed the  host factors,  using both an in vitro and in vivo approach.  Monoherbal compounds from species well-known in ayurvedic system of medicine, Phyllanthus amarus, Andrographis paniculata and Sillybum marianum are currently under investigation at ILBS. Initial wringer of the effect of these phytochemicals on expression of protective proteins like NFkB, COX2, PI3K/Akt, MAPK, or ERK has provided promising results. Some of the compounds like sylimarin and phyllanthin have shown to behepatoprotective potential. On the other hand compounds like andrographolide are proving to be constructive as antiviral. Investigations have revealed that the phytochemicals have lesser cytotoxicity to the host cells than the increasingly popular tenefovir, lamividin, adefovir, telbivudin and entecavir (currently stuff employed for the treatment of chronic hepatitis B). Recent studies have demonstrated that these phytochemicals have the potential to reactivate anti-tumor protein p53. This has far reaching consequences in chronic HBV and hepatocellular carcinoma treatment. Hepatitis C Chronic infection with hepatitis C virus (HCV) is a major rationalization of cirrhosis, liver disease, and hepatocellular carcinoma. The group is particularly interested in developing replicon system of HCV viral genome 3a which is an important tool, expressly in Indian perspective where increasingly than 80% of HCV patients are infected with this genotype. Replicons are required to determine the impact of mutations for drug resistance, but moreover to develop phenotypic resistance assays similar to those described for HIV or HBV. Such tools may be helpful to optimise treatment regimens. HCV replicons may moreover be instrumental in largest understanding the mechanisms underlying IFN-a mediated inhibition of HCV replication and to identify viral and host determinants of IFN- a resistance. There is moreover the possibility to produce infectious virus particles using HCV replicon system. This system will offer a new way to evaluate the role of neutralizing antibodies present in chronically infected patients. We have succeeded in making both sub-genome and full genome construct of HCV genotype 3a virus. Hepatitis E Unlike west, in India infection with Hepatitis E is a major health concern.Uppermortality is associated with HEV infection during the third trimester of pregnancy. And likewise vertical transmission to newborns is moreover a major rationalization of concern. Approximately 50% of vigilant viral hepatitis in young adults and in pregnant women is due to Hepatitis E virus (HEV) infection in developing countries. Hepatitis E is self resolving viral infection, however, in pregnant females, HEV infection can be serious. Nearly, 70-80% pregnant women well-spoken the virus without HEV infection; however, in 20-30%, HEV infection can wilt fatal. HEV can moreover induce chronic hepatitis in immunosuppressed patients. T lamina mediated immune injury probably plays a key role in the pathogenesis of vigilant hepatitis illness (Trehanpati et al 2011). During efficient host response, dendritic cells (DCs) and macrophages sense HEV through TLRs and secrete chemokines thereby vitalizing the T cells which get recruited in liver. Download e-Yakrit Download e-Yakrit Download iLiverCare Photo Gallery Video Gallery Quick Links Admissions Govt. 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